Colon Cancer Chemotherapy:
As one of the treatment options for colon cancer, chemotherapy uses drugs to stop the growth of cancer cells. The drugs either kill the cancer cells or stop them from dividing. Chemotherapy may be administered orally, injected into a vein, or placed directly in an area of the body. When used to treat people with colon cancer, chemotherapy may cause side effects, including an increased risk of infection, hair loss,An Overview of Colon Cancer Chemotherapy
Chemotherapy for colon cancer uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. When chemotherapy is taken orally or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body. This is called systemic chemotherapy. When chemotherapy is placed directly into the spinal column, an organ, or a body cavity (such as the abdomen), the drugs mainly affect cancer cells in those areas. This is called regional chemotherapy.
Chemoembolization of the hepatic artery may be used for colon cancer treatment when the cancer has spread to the liver. This involves blocking the hepatic artery (the main artery that supplies blood to the liver) and injecting anticancer drugs between the blockage and the liver. The liver's arteries then deliver the drugs throughout the liver. Only a small amount of the drug reaches other parts of the body. The blockage may be temporary or permanent, depending on what is used to block the artery. The liver continues to receive some blood from the hepatic portal vein, which carries blood from the stomach and intestine.
The way the colon cancer chemotherapy is administered depends on the stage of colon cancer being treated.
Side Effects Associated With Colon Cancer Chemotherapy
Side effects associated with colon cancer chemotherapy depend mainly on the specific drugs used and the dose. In general, anticancer drugs affect cells that divide rapidly, especially:
•Blood cells. These cells fight infection, help the blood to clot, and carry oxygen to all parts of the body. When drugs affect blood cells, patients are more likely to get infections, bruise or bleed easily, or feel very weak and tired.
•Cells in hair roots. Chemotherapy can cause hair loss. The hair grows back, but sometimes the new hair is somewhat different in color and texture.
•Cells that line the digestive tract. Chemotherapy can cause poor appetite, nausea and vomiting, diarrhea, or mouth and lip sores. Many of these side effects can be controlled with drugs. nausea, vomiting, and lip sores.
Showing posts with label colon. Show all posts
Showing posts with label colon. Show all posts
colon cancer symptoms
What is the Colon?
In order to understand what colon cancer symptoms might feel like, it helps to learn a bit about the colon. The colon is an important part of the digestive system, and as such, it has a major role in helping the body absorb nutrients, minerals, and water. The colon also helps rid the body of waste in the form of stool. The colon makes up the majority of the large intestine, approximately six feet in length. The last six inches or so of the large intestine are the rectum and the anal canal.
What are the Symptoms of Colon Cancer?
Colon cancer can have many symptoms. However, in the early stages, people with colon cancer often have no symptoms at all. This is why regular screening beginning at 50 is an important investment in your healthy future.
Colon cancer symptoms come in two general varieties:
1.Local
2.Systemic
Local Colon Cancer Symptoms
Local colon cancer symptoms affect your bathroom habits and the colon itself. Some of the more common local symptoms of colon cancer include:
•Changes in your bowel habits, such as bowel movements that are either more or less frequent than normal
•Constipation (difficulty having a bowel movement or straining to have a bowel movement)
•Diarrhea (loose or watery stools)
•Intermittent (alternating) constipation and diarrhea
•Bright red or dark red blood in your stools or black, dark colored, "tarry" stools
•Stools that are thinner than normal ("pencil stools") or feeling as if you cannot empty your bowels completely
•Abdominal (midsection) discomfort, bloating, frequent gas pains, or cramps
If you experience any of these for two or more weeks, call your doctor right away to discuss your concerns and arrange for tests to get to the bottom of your symptoms.
Systemic Colon Cancer Symptoms
Systemic colon cancer symptoms are those that affect your whole body, such as weight loss, and include:
•Unintentional weight loss (losing weight when not dieting or trying to lose weight)
•Loss of appetite
•Unexplained fatigue (extreme tiredness)
•Nausea or vomiting
•Anemia (low red blood cell count or low iron in your red blood cells)
•Jaundice (yellow color to the skin and whites of the eyes)
If you experience any of these for any length of time, even a few days, call your doctor right away to discuss your concerns and arrange for tests to get to the bottom of your symptoms.
What Should I Do if I Have Colon Cancer Symptoms?
Call your doctor so he or she can set up an appointment to see you. During the appointment your doctor will take a medical history, collect blood samples for testing, and schedule you for follow-up tests, if needed.
Many people are afraid of colon cancer screening. They worry that it will hurt and that it is embarrassing. Your doctor and nurse have performed hundreds, and in some cases even thousands, of these procedures. There is nothing to be embarrassed about and remember: Even your doctor and nurse undergo these same tests to take care of their own health.
Preparing for Colon Cancer Tests
If you are worried about preparing for your colon cancer tests, ask your doctor about how best to get ready for any procedures. There are different medications for clearing your colon of stool to ensure a good screening. There is no reason to suffer in silence!
Diagnosis of Colon Cancer and How Not to Dread Colon Cancer Screening provide detailed information on screening procedures, plus tips on how to make preparing for these tests easier.
In order to understand what colon cancer symptoms might feel like, it helps to learn a bit about the colon. The colon is an important part of the digestive system, and as such, it has a major role in helping the body absorb nutrients, minerals, and water. The colon also helps rid the body of waste in the form of stool. The colon makes up the majority of the large intestine, approximately six feet in length. The last six inches or so of the large intestine are the rectum and the anal canal.
What are the Symptoms of Colon Cancer?
Colon cancer can have many symptoms. However, in the early stages, people with colon cancer often have no symptoms at all. This is why regular screening beginning at 50 is an important investment in your healthy future.
Colon cancer symptoms come in two general varieties:
1.Local
2.Systemic
Local Colon Cancer Symptoms
Local colon cancer symptoms affect your bathroom habits and the colon itself. Some of the more common local symptoms of colon cancer include:
•Changes in your bowel habits, such as bowel movements that are either more or less frequent than normal
•Constipation (difficulty having a bowel movement or straining to have a bowel movement)
•Diarrhea (loose or watery stools)
•Intermittent (alternating) constipation and diarrhea
•Bright red or dark red blood in your stools or black, dark colored, "tarry" stools
•Stools that are thinner than normal ("pencil stools") or feeling as if you cannot empty your bowels completely
•Abdominal (midsection) discomfort, bloating, frequent gas pains, or cramps
If you experience any of these for two or more weeks, call your doctor right away to discuss your concerns and arrange for tests to get to the bottom of your symptoms.
Systemic Colon Cancer Symptoms
Systemic colon cancer symptoms are those that affect your whole body, such as weight loss, and include:
•Unintentional weight loss (losing weight when not dieting or trying to lose weight)
•Loss of appetite
•Unexplained fatigue (extreme tiredness)
•Nausea or vomiting
•Anemia (low red blood cell count or low iron in your red blood cells)
•Jaundice (yellow color to the skin and whites of the eyes)
If you experience any of these for any length of time, even a few days, call your doctor right away to discuss your concerns and arrange for tests to get to the bottom of your symptoms.
What Should I Do if I Have Colon Cancer Symptoms?
Call your doctor so he or she can set up an appointment to see you. During the appointment your doctor will take a medical history, collect blood samples for testing, and schedule you for follow-up tests, if needed.
Many people are afraid of colon cancer screening. They worry that it will hurt and that it is embarrassing. Your doctor and nurse have performed hundreds, and in some cases even thousands, of these procedures. There is nothing to be embarrassed about and remember: Even your doctor and nurse undergo these same tests to take care of their own health.
Preparing for Colon Cancer Tests
If you are worried about preparing for your colon cancer tests, ask your doctor about how best to get ready for any procedures. There are different medications for clearing your colon of stool to ensure a good screening. There is no reason to suffer in silence!
Diagnosis of Colon Cancer and How Not to Dread Colon Cancer Screening provide detailed information on screening procedures, plus tips on how to make preparing for these tests easier.
colon cancer
Colon cancer is cancer that starts in the large intestine (colon) or the rectum (end of the colon). Such cancer is sometimes referred to as "colorectal cancer."
Other types of colon cancer, such as lymphoma, carcinoid tumors, melanoma, and sarcomas, are rare. In this article, use of the term "colon cancer" refers to colon carcinoma and not these rare types of colon cancer.
Causes
According to the American Cancer Society, colorectal cancer is one of the leading causes of cancer-related deaths in the United States. (However, early diagnosis often leads to a complete cure.)
There is no single cause for colon cancer. Nearly all colon cancers begin as noncancerous (benign) polyps, which slowly develop into cancer.
You have a higher risk for colon cancer if you have:
Cancer elsewhere in the body
Colorectal polyps
Crohn's disease
Family history of colon cancer
Personal history of breast cancer
Ulcerative colitis
Certain genetic syndromes also increase the risk of developing colon cancer.
What you eat may play a role in your risk of colon cancer. Colon cancer may be associated with a high-fat, low-fiber diet and red meat. However, some studies found that the risk does not drop if you switch to a high-fiber diet, so the cause of the link is not yet clear.
Smoking cigarettes is another risk factor for colorectal cancer.
Symptoms
Many cases of colon cancer have no symptoms. The following symptoms, however, may indicate colon cancer:
Abdominal pain and tenderness in the lower abdomen
Blood in the stool
Diarrhea, constipation, or other change in bowel habits
Intestinal obstruction
Narrow stools
Unexplained anemia
Weight loss with no known reason
Exams and Tests
With proper screening, colon cancer can be detected before symptoms develop, when it is most curable.
Your doctor will perform a physical exam and press on your belly area. The physical exam rarely shows any problems, although the doctor may feel a mass in the abdomen. A rectal exam may reveal a mass in patients with rectal cancer, but not colon cancer.
Imaging tests to diagnose colorectal cancer include:
Colonoscopy
Sigmoidoscopy
Note: Only colonoscopy can see the entire colon.
A fecal occult blood test (FOBT) may detect small amounts of blood in the stool, which could suggest colon cancer. However, this test is often negative in patients with colon cancer. For this reason, a FOBT must be done along with colonoscopy or sigmoidoscopy. It is also important to note that a positive FOBT doesn't necessarily mean you have cancer.
A complete blood count may show signs of anemia with low iron levels.
If your doctor learns that you do have colorectal cancer, more tests will be done to see if the cancer has spread. This is called staging.
Stage 0: Very early cancer on the innermost layer of the intestine
Stage I: Cancer is in the inner layers of the colon
Stage II: Cancer has spread through the muscle wall of the colon
Stage III: Cancer has spread to the lymph nodes
Stage IV: Cancer has spread to other organs
Treatment
Treatment depends partly on the stage of the cancer. In general, treatments may include:
Chemotherapy to kill cancer cells
Surgery to remove cancer cells
Radiation therapy to destroy cancerous tissue
Stage 0 colon cancer may be treated by removing the cancer cells, often during a colonoscopy. For stages I, II, and III cancer, more extensive surgery is needed to remove the part of the colon that is cancerous. (See: Colon resection)
There is some debate as to whether patients with stage II colon cancer should receive chemotherapy after surgery. You should discuss this with your oncologist.
Almost all patients with stage III colon cancer should receive chemotherapy after surgery for approximately 6 - 8 months. The chemotherapy drug 5-fluorouracil has been shown to increase the chance of a cure in certain patients.
Chemotherapy is also used to treat patients with stage IV colon cancer. Irinotecan, oxaliplatin, and 5-fluorouracil are the three most commonly used drugs. In addition, monoclonal antibodies, including cetuximab (Erbitux), panitumumab (Vectibix), and bevacizumab (Avastin) have been used alone or in combination with chemotherapy.
You may receive just one type, or a combination of the drugs. Capecitabine is a chemotherapy drug taken by mouth, and is similar to 5-fluorouracil.
For patients with stage IV disease that has spread to the liver, various treatments directed specifically at the liver can be used. This may include:
Burning the cancer (ablation)
Cutting out the cancer
Delivering chemotherapy or radiation directly into the liver
Freezing the cancer (cryotherapy)
Although radiation therapy is occasionally used in patients with colon cancer, it is usually used in combination with chemotherapy for patients with stage III rectal cancer.
Support Groups
For additional resources and information, see colon cancer support groups.
Outlook (Prognosis)
Colon cancer is, in almost all cases, a treatable disease if caught early.
How well you do depends on many things, including the stage of the cancer. In general, when treated at an early stage, the vast majority of patients survive at least 5 years after their diagnosis. (This is called the 5-year survival rate.) However, the 5-year survival rate drops considerably once the cancer has spread.
If the colon cancer does not come back (recur) within 5 years, it is considered cured. Stage I, II, and III cancers are considered potentially curable. In most cases, stage IV cancer is not curable.
Possible Complications
Cancer returning in the colon
Cancer spreading to other organs or tissues (metastasis)
Development of a second primary colorectal cancer
When to Contact a Medical Professional
Call your health care provider if you have:
Black, tar-like stools
Blood during a bowel movement
Change in bowel habits
Prevention
The death rate for colon cancer has dropped in the last 15 years. This may be due to increased awareness and screening by colonoscopy.
Colon cancer can almost always be caught in its earliest and most curable stages by colonoscopy. Almost all men and women age 50 and older should have a colon cancer screening. Patients at risk may need screening earlier.
For information on this procedure, see:
Colon cancer screening
Colonoscopy
Colon cancer screening can find precancerous polyps. Removing these polyps may prevent colon cancer.
Dietary and lifestyle modifications are important. Some evidence suggests that low-fat and high-fiber diets may reduce your risk of colon cancer.
The U.S. Preventive Services Task Force recommends against taking aspirin or other anti-inflammatory medicines to prevent colon cancer if you have an average risk of the disease -- even if someone in your family has had the condition. Taking more than 300 mg a day of aspirin and similar drugs may cause dangerous gastrointestinal bleeding and heart problems in some people.
Although low-dose aspirin may help reduce your risk of other conditions, such as heart disease, it does not lower the rate of colon cancer.
Other types of colon cancer, such as lymphoma, carcinoid tumors, melanoma, and sarcomas, are rare. In this article, use of the term "colon cancer" refers to colon carcinoma and not these rare types of colon cancer.
Causes
According to the American Cancer Society, colorectal cancer is one of the leading causes of cancer-related deaths in the United States. (However, early diagnosis often leads to a complete cure.)
There is no single cause for colon cancer. Nearly all colon cancers begin as noncancerous (benign) polyps, which slowly develop into cancer.
You have a higher risk for colon cancer if you have:
Cancer elsewhere in the body
Colorectal polyps
Crohn's disease
Family history of colon cancer
Personal history of breast cancer
Ulcerative colitis
Certain genetic syndromes also increase the risk of developing colon cancer.
What you eat may play a role in your risk of colon cancer. Colon cancer may be associated with a high-fat, low-fiber diet and red meat. However, some studies found that the risk does not drop if you switch to a high-fiber diet, so the cause of the link is not yet clear.
Smoking cigarettes is another risk factor for colorectal cancer.
Symptoms
Many cases of colon cancer have no symptoms. The following symptoms, however, may indicate colon cancer:
Abdominal pain and tenderness in the lower abdomen
Blood in the stool
Diarrhea, constipation, or other change in bowel habits
Intestinal obstruction
Narrow stools
Unexplained anemia
Weight loss with no known reason
Exams and Tests
With proper screening, colon cancer can be detected before symptoms develop, when it is most curable.
Your doctor will perform a physical exam and press on your belly area. The physical exam rarely shows any problems, although the doctor may feel a mass in the abdomen. A rectal exam may reveal a mass in patients with rectal cancer, but not colon cancer.
Imaging tests to diagnose colorectal cancer include:
Colonoscopy
Sigmoidoscopy
Note: Only colonoscopy can see the entire colon.
A fecal occult blood test (FOBT) may detect small amounts of blood in the stool, which could suggest colon cancer. However, this test is often negative in patients with colon cancer. For this reason, a FOBT must be done along with colonoscopy or sigmoidoscopy. It is also important to note that a positive FOBT doesn't necessarily mean you have cancer.
A complete blood count may show signs of anemia with low iron levels.
If your doctor learns that you do have colorectal cancer, more tests will be done to see if the cancer has spread. This is called staging.
Stage 0: Very early cancer on the innermost layer of the intestine
Stage I: Cancer is in the inner layers of the colon
Stage II: Cancer has spread through the muscle wall of the colon
Stage III: Cancer has spread to the lymph nodes
Stage IV: Cancer has spread to other organs
Treatment
Treatment depends partly on the stage of the cancer. In general, treatments may include:
Chemotherapy to kill cancer cells
Surgery to remove cancer cells
Radiation therapy to destroy cancerous tissue
Stage 0 colon cancer may be treated by removing the cancer cells, often during a colonoscopy. For stages I, II, and III cancer, more extensive surgery is needed to remove the part of the colon that is cancerous. (See: Colon resection)
There is some debate as to whether patients with stage II colon cancer should receive chemotherapy after surgery. You should discuss this with your oncologist.
Almost all patients with stage III colon cancer should receive chemotherapy after surgery for approximately 6 - 8 months. The chemotherapy drug 5-fluorouracil has been shown to increase the chance of a cure in certain patients.
Chemotherapy is also used to treat patients with stage IV colon cancer. Irinotecan, oxaliplatin, and 5-fluorouracil are the three most commonly used drugs. In addition, monoclonal antibodies, including cetuximab (Erbitux), panitumumab (Vectibix), and bevacizumab (Avastin) have been used alone or in combination with chemotherapy.
You may receive just one type, or a combination of the drugs. Capecitabine is a chemotherapy drug taken by mouth, and is similar to 5-fluorouracil.
For patients with stage IV disease that has spread to the liver, various treatments directed specifically at the liver can be used. This may include:
Burning the cancer (ablation)
Cutting out the cancer
Delivering chemotherapy or radiation directly into the liver
Freezing the cancer (cryotherapy)
Although radiation therapy is occasionally used in patients with colon cancer, it is usually used in combination with chemotherapy for patients with stage III rectal cancer.
Support Groups
For additional resources and information, see colon cancer support groups.
Outlook (Prognosis)
Colon cancer is, in almost all cases, a treatable disease if caught early.
How well you do depends on many things, including the stage of the cancer. In general, when treated at an early stage, the vast majority of patients survive at least 5 years after their diagnosis. (This is called the 5-year survival rate.) However, the 5-year survival rate drops considerably once the cancer has spread.
If the colon cancer does not come back (recur) within 5 years, it is considered cured. Stage I, II, and III cancers are considered potentially curable. In most cases, stage IV cancer is not curable.
Possible Complications
Cancer returning in the colon
Cancer spreading to other organs or tissues (metastasis)
Development of a second primary colorectal cancer
When to Contact a Medical Professional
Call your health care provider if you have:
Black, tar-like stools
Blood during a bowel movement
Change in bowel habits
Prevention
The death rate for colon cancer has dropped in the last 15 years. This may be due to increased awareness and screening by colonoscopy.
Colon cancer can almost always be caught in its earliest and most curable stages by colonoscopy. Almost all men and women age 50 and older should have a colon cancer screening. Patients at risk may need screening earlier.
For information on this procedure, see:
Colon cancer screening
Colonoscopy
Colon cancer screening can find precancerous polyps. Removing these polyps may prevent colon cancer.
Dietary and lifestyle modifications are important. Some evidence suggests that low-fat and high-fiber diets may reduce your risk of colon cancer.
The U.S. Preventive Services Task Force recommends against taking aspirin or other anti-inflammatory medicines to prevent colon cancer if you have an average risk of the disease -- even if someone in your family has had the condition. Taking more than 300 mg a day of aspirin and similar drugs may cause dangerous gastrointestinal bleeding and heart problems in some people.
Although low-dose aspirin may help reduce your risk of other conditions, such as heart disease, it does not lower the rate of colon cancer.
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